HEALTHY MINDS with Dr. Jeffrey Borenstein

#1001 New Psychiatric Medications, part 1

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Ketamine and S-Ketamine target a different chemical system than many traditional medications for depression with rapid benefits and reduced suicide risk when part of a clinic-based overall treatment plan; a synthetic version of the hormone lost in childbirth may help patients with post-partum depression. Guest: John Krystal, MD, Chair, Department of Psychiatry, Yale School of Medicine.

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Ketamine as effective treatment for depression; a synthetic hormone treats post-partum depression.


#1002 New Psychiatric Medications, part 2

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New approaches to psychosis and schizophrenia treat symptoms without the side effects of traditional dopamine blockers; the potential for psychedelics to normalize brain function in depression within a psychotherapy framework; possible psychiatric use of GLP-1 medication to manage side effects and symptoms. Guest: John Krystal, MD., Chair, Department of Psychiatry, Yale School of Medicine.

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Treating psychosis with less side effects; psychedelics for depression; psychiatric use of GLP-1.


#1003 Alzheimer’s Disease: Diagnosis & Treatment

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New advances in blood tests for biomarkers mean earlier diagnosis and defined categories of Alzheimer’s disease enabling doctors to delay onset of symptoms, with lower costs to patients and higher accuracy. Guest:Howard Fillit, M.D., Co-Founder and Chief Science Officer, Alzheimer’s Drug Discovery Foundation.

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Blood tests that show biomarkers for Alzheimer’s disease can delay onset of symptoms.


#1004 Motivated Behavior: Training Your Brain

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The biology of behavior offers tools for a holistic approach to increase good habits and decrease bad habits including how talk therapy, exposure therapy, meditation and spirituality and more can impact the brain’s pre-frontal cortex to regulate emotion and decision making. Guest:Nii Addy, Ph.D, Albert E. Kent Associate Professor of Psychiatry, Yale School of Medicine.

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The biological impact on the brain of meditation and community in addition to traditional therapies.


#1005 Borderline Personality Disorder

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Borderline Personality Disorder patients now have access to several effective therapies including dialectical behavioral therapy, mentalization based therapy and psychiatric management with goals of self-reliance. Guest: Lois W. Choi-Kain, MD. M.Ed., Director, Gunderson Personality Disorders Institute, Associate Professor of Psychiatry, Harvard Medical School.

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Goal-oriented care for Borderline Personality Disorder now has positive outcomes.


#1006 Binge Drinking and Alcohol Misuse

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How excessive alcohol use - especially begun during adolescence - impacts somatostatin levels in the brain causing anxiety, depression, and future cognitive decline, as well as permanent changes to mood and the brain’s pre-frontal cortex. Guest: Nicole Crowley, Ph.D., Director, Penn State Neuroscience Institute University Park, Associate Professor of Biology and Biomedical Engineering.

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How excessive alcohol use in adolescence causes temporary and permanent changes to brain function.


#1007 Hoarding Disorder

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How excessive acquisition and difficulty discarding possessions leads to hoarding, the genetic and emotional components of the disorder, benefits of cognitive behavior therapy and virtual reality therapy, and how to help family members who don’t recognize their problem. Guest: Carolyn Rodriguez, MD., Ph.D., Professor of Psychiatry and Behavioral Sciences, Stanford University School of Medicine.

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Cognitive behavior and virtual reality therapies for excessive acquisition, difficulty discarding.


#1008 Eating Disorders and Self-Control

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Innovative research uses mathematical models, brain imaging, and behavior assessments to understand and treat the underlying issues of bulimia nervosa and binge eating. Guest: Laura A. Berner, Ph.D., Associate Professor of Psychiatry, Principal Investigator, Center for Computational Psychiatry, Center of Excellence in Eating and Weight Disorders, Icahn School of Medicine at Mount Sinai.

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Using mathematical models and brain imaging to understand bulimia nervosa and binge eating.


#1009 Mental Illness and The Criminal Justice System

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Exploring the unique issues when someone with a psychiatric or neurodevelopmental condition is brought into the criminal justice system as a result of their symptoms or behaviors, including the best way to proceed in that situation, preventative measures, and the value of an independent forensic mental health evaluation for diagnosis and testimony. Guest: Criminal attorney Elizabeth Kelley.

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Navigating the issues of mental illness diagnosis and competency for trial.


#1010 Autism, part 1

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The key factors for diagnostic assessment of autism – developmental history, degree of symptoms, eye contact, and motor behaviors; studies of genetics and infant eye gaze may lead to earlier diagnosis and intervention. Guest: John N. Constantino, MD, Liz and Frank Blake Chair of Children’s Behavioral and Mental Health, and Chief of Behavioral and Mental Health at Children’s Healthcare of Atlanta.

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Assessing developmental history, degree of symptoms, eye contact, motor behaviors, and genetics.


#1011 Autism, part 2

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The importance of access to early intervention and the right education plan for autistic children; considering the issues unique to the transition from childhood through adolescence and adulthood with autism. Guest: John N. Constantino, MD., Liz and Frank Blake Chair of Children’s Behavioral & Mental Health, and Chief of Behavioral and Mental Health at Children’s Healthcare of Atlanta.

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Prioritizing early intervention and education plans to give autistic children more opportunity.


#1012 Growing Brain Cells in The Lab

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Research pioneers turn skin cells from patients with psychiatric conditions into stem cells and then brain cells in cultures to learn how disorders arise to potentially develop therapeutics. Guest: Sergiu P. Pasca, MD, Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Founding Director, Stanford Brain Organogenesis Program, Stanford University.

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Pioneering work turns stem cells into brain cells in cultures to potentially treat disorders.


#1013 Treatment of Psychosis in Teens and Young Adults

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The importance of education about symptoms and early intervention to reduce the duration of untreated psychosis, and the value of programs for young people that use a team approach and peer support for patients and their families; substance-induced psychotic disorder and suicide prevention. Guest: Robert O. Cotes, MD., Professor of Psychiatry, Emory University School of Medicine.

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Symptom education for early intervention, and the benefits of a team approach with peer support.